The vacuum charging machine is used for automatically charging materials for V-mixers, twin-cone mixers, three-dimensional motion mixers and two-dimensional motion mixers. This vacuum charging machine independently carries out material charging functions for different mixers without the need for external vacuum generators or lifting devices. It is comprised of a portable frame, vacuum pump, powder recovery barrel, and secondary filtering purifier portable frame. With a smooth surface and easy operation, this vacuum charging machine is in full compliance with GMP standards.